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4 edition of Are current pediatric dose recommendations for intravenous theophylline appropriate? found in the catalog.

Are current pediatric dose recommendations for intravenous theophylline appropriate?

Kathleen Shilalukey

Are current pediatric dose recommendations for intravenous theophylline appropriate?

by Kathleen Shilalukey

  • 293 Want to read
  • 21 Currently reading

Published by National Library of Canada in Ottawa .
Written in English


Edition Notes

Thesis (M.Sc.)--University of Toronto, 1993.

SeriesCanadian theses = Thèses canadiennes
The Physical Object
FormatMicroform
Pagination2 microfiches : negative.
ID Numbers
Open LibraryOL15085894M
ISBN 100315835702
OCLC/WorldCa31514946

In children, low-dose theophylline may be used as a controller at step 2 but is less effective than inhaled corticosteroids. Intravenous aminophylline is not recommended for acute severe asthma. The Global Initiative for Chronic Obstructive Lung Disease recommends that theophylline be used as a bronchodilator only if inhaled long-acting. Safety Reporting Updates - Pediatric Advisory Committee Recommendations and Subsequent Outcomes Pediatric Study Characteristics Database List of Exclusivity Determinations (PDF - KB).

Recommendations and Guidelines. Appropriate Dosing for Parenteral Nutrition: Persistent shortages of parenteral nutrition (PN) components have led to a tendency of practitioners providing less than adequate dosing, which can lead to nutrient deficiencies and impair growth and document provides the requirements and recommendations for dosing of nutrients for a complete PN . Initially, 80 mg IV infused every 12 hours. Approximately 80% of patients may require dosage increase to 80 mg IV every 8 hours. Maximum dosage is mg/day IV, given in divided doses every 8—12 hours. Total daily IV doses of — mg effectively controlled gastric acid output within 1 hour and maintained acid control for up to 7 days.

In this study, patients were administered an initial bolus of IV aminophylline, and dosing was adjusted to maintain theophylline levels 4–8 μg/mL. In this previous study, a large proportion (20%) had side effects including agitation, increased nasogastric output, cardiac ectopy, and tachydysrhythmias. Maintenance intravenous fluids (IVFs) are used to provide critical supportive care for children who are acutely ill. IVFs are required if sufficient fluids cannot be provided by using enteral administration for reasons such as gastrointestinal illness, respiratory compromise, neurologic impairment, a perioperative state, or being moribund from an acute or chronic illness.


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Are current pediatric dose recommendations for intravenous theophylline appropriate? by Kathleen Shilalukey Download PDF EPUB FB2

Usual Pediatric Dose for Asthma - Acute. Intravenous theophylline in dextrose: Loading dose, no theophylline in the previous 24 hours: mg/kg ideal body weight, intravenously over 30 minutes, results in an average 10 mcg/mL (range 6 to 16) serum theophylline concentration.

J Asthma. ;30(2) Are current pediatric dose recommendations for intravenous theophylline appropriate. Shilalukey K(1), Robieux I, Spino M, Greenwald M, Shear N, Koren by: 8. Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of theophylline injection in children.

However, children younger than 1 year of age are more likely to have serious side effects, which may require caution and an adjustment in the dose for patients receiving theophylline.

Introduction. Intravenous aminophylline can be used to manage exacerbations of asthma in children who do not respond to first line inhaled/nebulised therapy [].Accurate dosing is important, to ensure adequate asthma treatment, whilst reducing toxicity [2–4].Aminophylline has a widely accepted therapeutic range of mg/l, which drives dosing decisions in children [1,5].Cited by: 4.

Objective: To assess the evidence underpinning recommendations for a target theophylline level between mg/l in children suffering an acute exacerbation of asthma.

Methods: A systematic review comparing outcomes of children who achieved serum theophylline concentrations between mg/l with those who did not. Primary outcomes were time until resolution of symptoms, Author: Lewis Cooney, Daniel Hawcutt, Daniel Hawcutt, Ian Sinha.

Optimizing the management of children presenting with acute severe asthma is of utmost importance to minimize hospital stays, morbidity, and mortality. Intravenous medications, including theophyllines, are used as second-line treatments for children experiencing a life-threatening exacerbation.

For intravenous theophylline (aminophylline), guidelines and formularies recommend a target. CURRENT OPINION Optimizing the Dosing of Intravenous Theophylline in Acute Severe Asthma in Children Gemma L. Saint1 • Malcolm G. Semple1 • Ian Sinha1 • Daniel B.

Hawcutt1,2 Published online: 5 January The Author(s) This article is an open access publication Abstract Optimizing the management of children pre.

The majority (64%) of the dosing errors by physicians involved theophylline in capsule or tablet form in doses above age- and weight-specific recommendations:t Although the avoidance of foul taste and the convenience of sustained-release preparations make their use attractive, accurate dosing is a more important consideration.

Pediatric Guidelines for IV Medication Administration NOTE: This is not a comprehensive medication list. For items not listed, review standard medication resources or consult the pharmacist. Version 9/28/ Barb Maas Pharm. 1 Approved For Drug Administration ICU ED Telemetry Required Acute Care IVP IV Infusion Concent-ration Usual Dosing and.

PEDIATRIC DOSING GUIDELINES - ANALGESICS / SEDATIVES DRUG DOSE INTERVAL (hr) Acetaminophen 10 - 15 mg/kg/dose Q (Max: dose) Q (IV) - mg/kg/dose Q   In children years of age, the final theophylline dose should not exceed 16 mg/kg/day up to a maximum of mg/day in the presence of risk factors for reduced theophylline clearance (see WARNINGS) or if it is not feasible to monitor serum theophylline concentrations.

This statement provides current recommendations about the use of emergency drugs for acute pediatric problems that require pharmacologic intervention. At each clinical setting, physicians and other providers should evaluate drug, equipment, and training needs.

The information provided here is not all-inclusive and is not intended to be appropriate to every health care setting. Give Epinephrine in asolution: mg/kg by IV or IO every 3 to 5 minutes (or give Epinephrine in a, solution: mg/kg by ETT every 3 to 5 minutes) Atropine: mg/kg by IV or IO with a minimum single dose of mg and a maximum single dose of mg in a child (used for AV block and to increase vagal tone).

However, if the dosing interval is appropriate for the absorption rate of the product and elimination rate of the patient, serum concentrations generally can be maintained within the therapeutic range around the clock. 37 Absorption of theophylline from the so-called once-daily formulations is either incomplete, erratic, or too rapid to achieve.

Background Adequate asthma treatment of childhood exacerbations with IV aminophylline depends on appropriate dosage.

Recommendations to aim for a target therapeutic range may be inappropriate as serum concentrations correlate poorly with clinical improvement. This review aims to evaluate the evidence for the optimum dosage strategy of intravenous aminophylline in children.

Because of marked individual differences in the rate of theophylline clearance, the dose required to achieve a peak serum theophylline concentration in the mcg/mL range varies fourfold among otherwise similar patients in the absence of factors known to alter theophylline clearance (e.g., mg/day in adults.

The transition from intravenous (IV) to oral theophylline in patients hospitalized for asthma frequently is haphazard, with little regard for maintaining therapeutic levels.

This study, involving 14 pediatric patients, investigated several methods of transition from IV to oral, sustained-release theophylline.

dose of cyclophosphamide as well as that of the other drugs. Dosing for Minimal Change Nephrotic Syndrome in Pediatric Patients An oral dose of 2 mg per kg daily for 8 to 12 weeks (maximum cumulative dose mg per kg) is recommended.

Treatment beyond 90 days increases the probability of sterility in males [see Use in Specific Populations (   *Recent publications suggest the efficacy of shorter courses of treatment for early Lyme disease. NOTE: For people intolerant of amoxicillin, doxycycline, and cefuroxime axetil, the macrolides azithromycin, clarithromycin, or erythromycin may be used, although they have a lower efficacy.

People treated with macrolides should be closely monitored to ensure that symptoms resolve. of theophylline is required, an intravenous (IV) for- mulation provides the most rapid and ensured delivery of medication, but plain, uncoated or chewable tablets.

Pediatric formulations have been developed and are being tested in the ongoing studies. The key for use in children will be to have explicit age‐appropriate dosing information available. Whether and in which situations there will be the need for therapeutic drug monitoring and dose adaption in children .Antibiotic Dosing for Children: Expert Recommendations For Children Ages 2 months to 12 years Dosing Recommendations at a Glance Amikacin 15 mg/kg/day IV given once daily Cloxacillin, Flucloxacillin mg/kg/day IV divided in 2 or 4 doses Amoxicillin mg/kg/day PO divided in 2 or 3 doses Doxycycline 5 mg/kg/day given once daily or in 2 doses.Patients can be administered IV theophylline for acute bronchospasm.

Pediatric patients: The dose must be airways obstruction received microcrystalline theophylline in a dosage of mg.